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The C-87 transport derivative served as a longer range, higher capacity counterpart to the Douglas C-47 Skytrain.īy the end of World War II, the technological breakthroughs of the Boeing B-29 Superfortress and other modern types had surpassed the bombers that served from the start of the war. Long-range anti-submarine Liberators played an instrumental role in closing the Mid-Atlantic gap in the Battle of the Atlantic. Due to its range, it proved useful in bombing operations in the Pacific, including the bombing of Japan. Along with the B-17, the B-24 was the mainstay of the US strategic bombing campaign in the Western European theater. It saw use in every theater of operations. It served in every branch of the American armed forces as well as several Allied air forces and navies. ![]() The B-24 was used extensively in World War II. At approximately 18,500 units – including 8,685 manufactured by Ford Motor Company – it holds records as the world's most produced bomber, heavy bomber, multi-engine aircraft, and American military aircraft in history. While aircrews tended to prefer the B-17, General Staff favored the B-24 and procured it in huge numbers for a wide variety of roles. In comparison with its contemporaries, the B-24 was relatively difficult to fly and had poor low-speed performance it also had a lower ceiling and was less robust than the Boeing B-17 Flying Fortress. Early RAF Liberators were the first aircraft to cross the Atlantic Ocean as a matter of routine. The wing gave the Liberator a high cruise speed, long range and the ability to carry a heavy bomb load. It was known within the company as the Model 32, and some initial production aircraft were laid down as export models designated as various LB-30s, in the Land Bomber design category.Īt its inception, the B-24 was a modern design featuring a highly efficient shoulder-mounted, high aspect ratio Davis wing. The Consolidated B-24 Liberator is an American heavy bomber, designed by Consolidated Aircraft of San Diego, California. ![]() There were 794 patients enrolled in this study, and it was designed so that 532 patients got treatment after their surgery with the immunotherapy drug, and 262 got placebo, which was the standard of care, as close observation following surgery for esophageal and gastroesophageal junction cancers is what oncologists have been trained to do up to this point. ![]() Looking at the geographical breakdown, 32% of the patients were from the US and Canada, 38% were from Europe, 13% from Asia and then just over 16% were from other parts of the World. This trial was sponsored by Bristol Myers Squibb, and it enrolled patients from 170 centers across 29 countries. How many patients participated, what did the study involve? Tell us more about the study that led to today’s FDA approval. This should provide our patients considerable hope for a brighter future, and it provides treating oncologists more tools for the fight. I anticipate many more advances in the future utilizing immunotherapy drugs in early stage cancers to prevent disease recurrence. This study specifically looked at those with esophageal and gastroesophageal junction cancers. And so immune cells can now start attacking tumors, and we're seeing amazing advances – for the first time – in patients with early stage, operable cancers to prevent the cancer from coming back. These drugs, called PD-1 inhibitors, prevent the tumor from doing that. Here’s how: Typically, when immune cells are close to a tumor, the tumor tries to defend itself by utilizing a certain protein called PD-1 to prevent a patient’s own immune system from attacking the cancer cells. The CheckMate 577 study proved we can give these drugs to prevent a patient’s tumor from hiding from immune cells. ![]() What we haven't had – with the exception of melanoma – is the use of these drugs in earlier-stage disease. So far, seven of these drugs have been approved for use across a wide range of metastatic cancers and it is now standard of care for patients with inoperable advanced malignancies to receive a PD-1 inhibitor. Nivolumab is a medication, called a PD-1 inhibitor, and these drugs are designed to prevent the cancer from hiding from your immune system. Just as we're all now getting vaccinated to “turn on” our immune system against the COVID-19 virus, what the FDA approved today is an immunotherapy drug that can help the body’s immune system in the fight against early stage cancers. This is why we say it really signifies the start of a whole new era in cancer care, where patients with early stage operable tumors, who may be at risk of recurrence, can get an immunotherapy drug to prevent the tumor from coming back. This phase III global study which enrolled 794 patients across 29 countries and 174 study sites showed that we can double the disease-free survival when nivolumab is used as an adjuvant therapy in the post-operative setting. As a result of the CheckMate 577 trial and today’s FDA approval, we now have a new treatment option: patients with early stage esophageal cancers still get trimodality therapy, but now we add immunotherapy after they've recovered from their surgery. ![]() This is important for our patients, as it is moving immunotherapy drugs beyond treatment for metastatic, advanced cancers and into treatment for early stage, operable tumors.įor example, before this trial, patients with early stage esophageal cancers were treated with chemotherapy, radiation and surgery (trimodality therapy). This is a major step – one that we believe is the start of a new era of cancer care. Today, the FDA approved nivolumab, an immunotherapy drug that was shown in a clinical trial to double disease-free survival in patients with early stage tumors. What do patients need to know about the significance of the FDA’s approval of nivolumab? A major advancement for cancer patients has happened today, stemming from clinical research that was conducted right here in Dallas. ![]() Instead of treating ships as a single piece of equipment, like a gun or a squad, they are now treated as complex systems that incur damage in combat. The developers and managers wants to offer more scenarios (expansion in Europe and elsewhere) and also other epochsįlashpoint Campaigns: Red Storm would be an easy to mod System, it seems to be so flexible and comprehensive, that we may well expect additional scenarios and mods from the community.Įven the more modern design and UI speak for Flashpoint Campaigns : Red Storm.Īnd we have the dedicated support of developers and other stakeholders. The Operational Art of War IV is the top-notch military simulation that every wargamer needs New naval warfare features: The modeling of ships has been improved. 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The Operational Art of War IV is the top-notch military simulation that every wargamer needs FEATURES New naval warfare features The modeling of ships has been improved. With more flexibility than before and with a new array of exciting features. Is one of the most comprehensive strategy games ever. The Operational Art of War IV is the new generation of operational wargames. That’s why we have decided to publish the full list of the accessible scenarios, to give you a nice overview of the historical depth available. With more flexibility than before and with a new array of exciting features, The. The Operational Art of War IV minimum requirements Memory: 512 MB Graphics Card: ATI FireGL T2-128 CPU: Intel Pentium 4 2.00GHz File Size: 650 MB OS. The Operational Art of War IV Scenario List socials Published on NovemMany of you have wondered what scenarios will be included, how many from TOAW III, how many completely new ones, and so on. 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When you install any Mod in Subnautica, Please Enable the Mod in Vortex Mod installer and then Check for any advance settings here in the Game Go to Options > Mods and check for any Mods settings. Is it OK to mod GTA 5 Mods from and GTA5. Video Guide: How to use Subnautica Mods? List of Best 30+ Subnautica Mods that Made My Day: Next, go to the Mods tab here to begin browsing mods available on PC, PS4 and Xbox One. (Download the One-Click Installer its easy to install) Step 1: First Download and Install the Vortex Mod Installer free version by Nexus on your PC. ![]() Warning: You need to Signup and Login to download and Install these Subnautica Mods from Nexus Mod Community. And I will share all 30+ Mods list below this so you won’t get confused about which one to download. 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